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Those schedules were chosen because they produced the best combination of: Time to therapeutic dose (faster is better for adherence) Discontinuation rate due to adverse events (lower is better) Percentage of patients reaching target dose (higher is better) The STEP-1 trial (Wilding et al., New England Journal of Medicine , 2021) reported that 4.5% of semaglutide patients discontinued due to gastrointestinal adverse events when starting at 0.25 mg
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